Brain connections are more sophisticated than thought

Inhibitory connections between neurons act as the brain’s brakes, preventing it from becoming overexcited. Researchers thought inhibitory connections were less sophisticated than their excitatory counterparts because relatively few proteins were known to exist at these structures. But a new study overturns that assumption, uncovering 140 proteins that have never been mapped to inhibitory synapses. Some of the proteins have already been implicated in autism, intellectual disability and epilepsy, …

Inhibitory connections between neurons act as the brain’s brakes, preventing it from becoming overexcited. Researchers thought inhibitory connections were less sophisticated than their excitatory counterparts because relatively few proteins were known to exist at these structures. But a new study overturns that assumption, uncovering 140 proteins that have never been mapped to inhibitory synapses. Some of the proteins have already been implicated in autism, intellectual disability and epilepsy, …