How cells take out the trash: The 'phospho-kiss of death' deciphered

Cells never forget to take out the trash. It has long been known that cells tag proteins for degradation by labeling them with ubiquitin, a signal described as “the molecular kiss of death”. Now a research group has identified an analogous system in gram-positive bacteria, where the role of a degradation tag is fulfilled by a little known post-translational modification: arginine phosphorylation. The discovery opens new avenues for designing antibacterial therapies….

Cells never forget to take out the trash. It has long been known that cells tag proteins for degradation by labeling them with ubiquitin, a signal described as “the molecular kiss of death”. Now a research group has identified an analogous system in gram-positive bacteria, where the role of a degradation tag is fulfilled by a little known post-translational modification: arginine phosphorylation. The discovery opens new avenues for designing antibacterial therapies….