Major family of gene-regulating proteins has drug-sized pocket

An entire class of proteins called transcription factors has largely been ignored by the pharmaceutical industry because it’s difficult to design and screen drugs against them. But a new study suggests that a key group of transcription factors are in fact ‘druggable,’ including several that could be targeted to treat cancer, metabolic disease, or autoimmune conditions….

An entire class of proteins called transcription factors has largely been ignored by the pharmaceutical industry because it’s difficult to design and screen drugs against them. But a new study suggests that a key group of transcription factors are in fact ‘druggable,’ including several that could be targeted to treat cancer, metabolic disease, or autoimmune conditions….