Structural deficits may explain mood-independent cognitive difficulties in bipolar disorder

Using magnetic resonance imaging (MRI), a new study reports a link between reduced functional activation and reduced cortical thickness in the brains of patients with bipolar disorder. The abnormalities were found in patients not currently experiencing depression or mania, which suggests that there is a structural basis for altered neural processing that may help explain why cognitive deficits persist even during periods of normal mood….

Using magnetic resonance imaging (MRI), a new study reports a link between reduced functional activation and reduced cortical thickness in the brains of patients with bipolar disorder. The abnormalities were found in patients not currently experiencing depression or mania, which suggests that there is a structural basis for altered neural processing that may help explain why cognitive deficits persist even during periods of normal mood….