Why is pancreatic cancer so hard to treat? Stroma provides new clues

Why are pancreatic tumors so resistant to treatment? One reason is that the ‘wound’-like tissue that surrounds the tumors, called stroma, is so dense, likely preventing cancer-killing drugs from reaching the tumor. A team has now discovered heterogeneity in the fibroblast portion of the stroma, opening up the possibility of targeted treatment….

Why are pancreatic tumors so resistant to treatment? One reason is that the ‘wound’-like tissue that surrounds the tumors, called stroma, is so dense, likely preventing cancer-killing drugs from reaching the tumor. A team has now discovered heterogeneity in the fibroblast portion of the stroma, opening up the possibility of targeted treatment….